Preliminary research in animal models suggests chronic stress may contribute to the development and progression of Parkinson's in various ways, such as inflammation, oxidative stress, and damage to dopamine-producing neurons in the brain.

Daily and chronic stressors can make both the motor (tremor, freezing, slowness of movement) and non-motor symptoms of Parkinson's feel worse (such as gut microbiome, constipation, sleep, anxiety, brain fog, fatigue, and pain).

Stress and Mindfulness in Parkinson's Disease: Clinical Effects and Potential Underlying Mechanisms (2020)